실험적으로 유도된 당뇨백서의 심근병증에 관한 조직병리학적 연구
Histopathological study on cardiomyopathy in experimentally induced diabetic rats
안진수, 이재훈,
소속 상세정보
안진수 ( ) - 단국대학교 치과대학 치과보존학교실
이재훈 ( ) - 단국대학교
KMID : 0360119960180030488
Abstract
Diabetes mellitus revealed a chronic disorder of lipid, carbohydrate and protein metabolism characterized by insulin deficiency, and a striking tendency toward development of atherosclerosis, microangiopathy, nephropathy, neuropathy and recently
cardiomyopathy etc.
The mechanism of heart failure in patients with diabetic cardiomyopathy is not clear but diabetic cardiomyopathy usually occurs in persons with long standing diabetes. After diabetes induced in male Sprague-Dawley strain rats by injection of
streptozotocin(60mg/kg), cardiac tissue with hematoxylin-eosin and Masson's trichrome stain was examined at 3 days, 1, 2, 4, 6 weeks later under light microscope.
@ES The results were obtained as follows :
@EN 1. In H&E stain of control group, myocardiac cells were shorter than skeletal muscle cell, which was branched out and connected each other at terminal with striation, intercalated disk and nucleus at center of cell.
2. In MT stain of control group, a few of collagen fibrile were seen at periva scular interstium, but wasn't seen between skeletal muscle fiber, and cardiac muscle was seen in various size.
3. In MT stain of experimental group, increased collagen fiber deposition at perivascular interstiums were seen periodically.
4. In MT stain of experimental group, incresed collagen fiber deposition at interstitial matrix between perimyocardiac cells were seen at 3 day, 4 weeks and 6 weeks after DM induction.
5. In H&E stain of experimental group, partial degeneration of myocardiac cells was seen after 4 weeks of DM induction.
From above results, streptozotocin induced diabetes mellitus increased collagen around perivascular and between intercellular matrix in heart.
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